The pit at Tycho sits right beneath Orion's Belt, which is sacred to the space god Osiris. It is here that the astronauts find the Monolith, the ancient alien artifact responsible for mankind's intellectual and technological evolution.
As was Osiris himself, according to the mythology. I'd say the odds of this being a "coincidence" are about ten-billion-squillion to one-one-thousandth of half a percent, especially given the fact that Orion is already name-checked in the film.
Also not coincidentally, the next manned mission to the Moon is the Orion 17.
A short post on Kirby's 2001 is here.